專業(yè)職稱:研究員
個人簡介:
[職稱] 教授,研究員
[學(xué)位] 博士研究生
[職務(wù)] 改革與發(fā)展處副處長,兼生物醫(yī)學(xué)創(chuàng)新中心副主任
教育背景/工作經(jīng)歷
1998.09~2002.07 北京大學(xué) 生物學(xué)、計算機軟件工程 學(xué)士
2003.09~2008.07 中國科學(xué)院北京基因組研究所 遺傳學(xué) 博士
2002.08~2009.09 華大基因 負責(zé)人 研究實習(xí)員
2009.09~2015.01 中國疾病預(yù)防控制中心傳染病所 副主任 副研究員
2015.02~2021.03 首都醫(yī)科大學(xué)附屬北京地壇醫(yī)院 教授 研究員
2021.04~至今 首都醫(yī)科大學(xué)附屬北京世紀壇醫(yī)院 教授 研究員
聯(lián)系方式
聯(lián)系電話:010-63926977
電子信箱:chenchen1@ccmu.edu.cn
中國醫(yī)療保健國際交流促進會分子診斷學(xué)分會 常務(wù)委員
中國生物工程學(xué)會生物信息學(xué)分會 常務(wù)委員
中國微生物學(xué)會微生物生物安全專業(yè)委員會 青年常務(wù)委員
北京市衛(wèi)生系統(tǒng)高層次衛(wèi)生技術(shù)人才培養(yǎng)計劃 北京市衛(wèi)計委
北京市科技新星計劃 北京市科委
先后獲得了國家自然科學(xué)基金2項,國家自然科學(xué)基金重點項目子課題1項,國家科技部863計劃子課題1項。2019年,獨立主持了國家科技部重點項目中英合作計劃。近10年,作為第一作者和通訊作者(含共同),發(fā)表SCI論文60余篇,單篇最高影響因子24.5,總引用3000余次。主要代表性論文包括: Cell子刊3篇(Cell Metabolisms, Molecular Cell及Cell Reports),Nature 子刊2篇(Nature Microbiology及Nature Communication),臨床代表性論文4篇(Annals of Internal Medicine, Clinical Infectious Diseases及Lancet Infectious Diseases)和國內(nèi)卓越期刊3篇(National Science Review, Innovation 及Genomics Proteomics Bioinformatics)等。
代表性論文:
1. Li J#, Du P#, Yang L#, Zhang J#, Song C#, Chen D#, Song Y, Ding N, Hua M, Han K, Song R, Xie W, Chen Z, Wang X, Liu J, Xu Y, Gao G, Wang Q, Pu L, Di L, Li J, Yue J, Han J, Zhao X, Yan Y, Yu F, Wu AR, Zhang F*, Gao YQ*, Huang Y*, Wang J*, Zeng H*, Chen C*. Two-step fitness selection for intra-host variations in SARS-CoV-2. Cell Rep. 2022 Jan 11;38(2):110205. doi: 10.1016/j.celrep.2021.110205. Epub 2021 Dec 16. PMID: 34982968; PMCID: PMC8674508.
2. Li NN#, Li W#, Feng JX#, Zhang WW, Zhang R, Du SH, Liu SY, Xue GH, Yan C, Cui JH, Zhao HQ, Feng YL, Gan L, Zhang Q, Chen C*, Liu D*, Yuan J*. High alcohol-producing Klebsiella pneumoniae causes fatty liver disease through 2,3-butanediol fermentation pathway in vivo. Gut Microbes. 2021 Jan-Dec;13(1):1979883. doi: 10.1080/19490976.2021.1979883. PMID: 34632939; PMCID: PMC8510565.
3. Chen Chen#, Guiju Gao#, Yanli Xu#, Lin Pu#, Qi Wang#, Liming Wang#, Wenling Wang, Yangzi Song, Meiling Chen, Linghang Wang, Fengting Yu, Siyuan Yang, Yunxia Tang, Li Zhao, Huijuan Wang, Yajie Wang, Hui Zeng*, Fujie Zhang*. 2020. Sars-Cov-2–Positive Sputum and Feces after Conversion of Pharyngeal Samples in Patients with Covid-19. Annals of Internal Medicine. 2020 Jun 16;172(12):832-834. doi: 10.7326/M20-0991. Epub 2020 Mar 30. PMID: 32227141; PMCID: PMC7133055.
4. Chen C#, Li J#, Di L#, Jing Q#, Du P#, Song C, Li J, Li Q, Cao Y, Xie XS, Wu AR*, Zeng H*, Huang Y*, Wang J*. MINERVA: A Facile Strategy for SARS-CoV-2 Whole-Genome Deep Sequencing of Clinical Samples. Mol Cell. 2020 Dec 17;80(6):1123-1134.e4. doi: 10.1016/j.molcel.2020.11.030. Epub 2020 Nov 20. PMID: 33290743; PMCID: PMC7678446.
5. Ju Zhang#, Nan Ding#, Lili Ren#, Rui Song#, Danying Chen#, Xuesen Zhao, Budong Chen, Junyan Han, Jiarui Li, Yangzi Song, Lin Di, Kai Han, Fengting Yu, Ruming Xie, Zhihai Chen, Wen Xie, Jingyuan Liu, Shan Cen, Yuhai Bi, Angela R Wu*, Fujie Zhang*, Chen Chen*, Hui Zeng*, COVID-19 reinfection in the presence of neutralizing antibodies, National Science Review, nwab006.
6. Pengcheng Du#, Nan Ding#, Jiarui Li#, Fujie Zhang#, Qi Wang#, Zhihai Chen#, Chuan Song, Kai Han, Wen Xie, Jingyuan Liu, Linghang Wang, Lirong Wei, Shanfang Ma, Mingxi Hua, Fengting Yu, Lin Wang, Wei Wang, Kang An, Jianjun Chen, Haizhou Liu, Guiju Gao, Sa Wang, Yanyi Huang, Angela R. Wu, Jianbin Wang*, Di Liu*, Hui Zeng* & Chen Chen*. Genomic surveillance of COVID-19 cases in Beijing. Nat Commun 11, 5503 (2020). https://doi.org/10.1038/s41467-020-19345-0.
7. Pengcheng Du#, Chuan Song#, Rui Li#, Yangzi Song#, Jiarui Li, Nan Ding, Ju Zhang, Rui Song, Junyan Han, Guiju Gao, Jinglin Yue, Ang Duan, Yanyi Huang, Jing An, Jianbin Wang*, Fujie Zhang*, Chen Chen*, Hui Zeng*. Specific Redistribution of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Respiratory System and Intestinal Tract. Clinical Infectious Diseases, ciaa1617.
8. Jing Yuan#,*, Chen Chen#, Jinghua Cui#, Jing Lu#, Chao Yan#, Xiao Wei, Xiangna Zhao, NanNan Li, Shaoli Li, Guanhua Xue, Weiwei Cheng, Boxing Li, Huan Li, Weishi Lin, Changyu Tian, Jiangtao Zhao, Juqiang Han, Daizhi An, Qiong Zhang, Hong Wei, Minghua Zheng, Xuejun Ma, Wei Li, Xiao Chen, Zheng Zhang, Hui Zeng, Sun Ying, JianXin Wu, Ruifu Yang*, Di Liu*. 2019. Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae. Cell Metabolism, 30(4): 675-688.e7.
9. Du P, Zhang Y, Chen C*. 2018. Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae. Lancet Infect Dis, 18(1):23-4.
10. Ni M#, Chen C#, Qian J#, Xiao HX, Shi WF, Luo Y, Wang HY, Li Z, Wu J, Xu PS, Chen SH, Wong G, Bi Y, Xia ZP, Li W, Lu HJ, Ma J, Tong YG, Zeng H, Wang SQ*, Gao GF*, Bo XC*, Liu D*. 2016. Intra-host dynamics of Ebola virus during 2014. Nat Microbiol, 1(11):16151.