曾輝研究員
免疫學(xué)。
專業(yè)職稱：研究員
個人簡介：
[職稱] 研究員，教授
[職務(wù)] 生物醫(yī)學(xué)創(chuàng)新中心主任
[學(xué)位] 生物學(xué)博士、醫(yī)學(xué)博士
教育背景/工作經(jīng)歷
1988-1993 首都醫(yī)科大學(xué)臨床醫(yī)學(xué)學(xué)士
1993-1996 首都醫(yī)科大學(xué)臨床醫(yī)學(xué)碩士
2000-2004 德國杜伊斯堡-埃森大學(xué)生物學(xué)博士 ( Ph.D./Dr.rer.nat. )
2004-2006 德國杜伊斯堡-埃森大學(xué)醫(yī)學(xué)博士 ( M.D./Dr. Med.)
1996-1998 首都醫(yī)科大學(xué)附屬北京同仁醫(yī)院血液內(nèi)科, 住院醫(yī)師、主治醫(yī)師
1998-2000 美國華盛頓大學(xué)醫(yī)學(xué)院血液科Senior research fellow
2004-2006 德國杜伊斯堡-埃森大學(xué)，博士后
2006-2021 首都醫(yī)科大學(xué)附屬北京地壇醫(yī)院，研究員、教授，傳染病研究所副所長、所長
2021年4月至今 首都醫(yī)科大學(xué)附屬北京世紀(jì)壇醫(yī)院生物醫(yī)學(xué)創(chuàng)新中心主任
中國醫(yī)師協(xié)會體外生命支持專業(yè)委員常務(wù)委員兼總干事
中國性病艾滋病防治協(xié)會艾滋病病毒學(xué)專業(yè)委員會 委員
新發(fā)突發(fā)傳染病北京市重點實驗室副主任
國家中醫(yī)藥管理局三級實驗室(感染免疫)主任
2021 華夏醫(yī)學(xué)科技獎二等獎
2020 北京市科學(xué)技術(shù)進(jìn)步獎二等獎
2018華夏醫(yī)學(xué)科技獎二等獎
2017中華醫(yī)學(xué)科技獎二等獎
2016北京市科學(xué)技術(shù)進(jìn)步獎三等獎
1998北京市科學(xué)技術(shù)進(jìn)步獎三等獎
作為第一作者和責(zé)任作者文章在Nature Communications、Molecular Cell、Cell Reports、Annals of Internal Medicine、EMBO Journal、National Science Review、Blood、British Journal of Hematology、Thorax、Clinical Cancer Research、Clinical Infectious Disease、Journal of Infectious Diseases, Aging Cell、Critical Care 、Signal Transduction and Targeted Therapy、AIDS等多學(xué)科領(lǐng)域發(fā)表論文。
代表性論文：
1) Li J, Du P, Yang L, Zhang J, Song C, Chen D, Song Y, Ding N, Hua M, Han K, Song R, Xie W, Chen Z, Wang X, Liu J, Xu Y, Gao G, Wang Q, Pu L, Di L, Li J, Yue J, Han J, Zhao X, Yan Y, Yu F, Wu AR, Zhang F, Gao YQ, Huang Y, Wang J, Zeng H, Chen C. Two-step fitness selection for intra-host variations in SARS-CoV-2. Cell Rep. 2022, 38:110205.
2) Zhang J, Ding N, Song Y, Song R, Pan Y, Wang L, Yan S, Wang Q, Ma S, Wei L, Yu F, Lu L, Zhang F, Chen C, Zeng H*. Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak. Innovation (NY). 2021, 2:100099.
3) Zhang Y, Han K, Du C, Li R, Liu J, Zeng H*, Zhu L, Li A. Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients. Crit Care. 2021, 25:51.
4) Zhang J, Ding N, Ren L, Song R, ChenD, Zhao X, Chen B, Han J, Li J, Song Y, Di L, Han K, Yu F, Xie R, Chen Z, Xie W, Liu J, Cen S, Bi Y, Wu RA, Zhang F, Chen C, Zeng H*. COVID-19 reinfection in the presence of neutralizing antibodies. Natl Sci Rev. 2021, 8: nwab006
5) Chen C, Li J, Di L, Jing Q, Du P, Song C, Li J, Li Q, Cao Y, Xie XS, Wu AR, Zeng H*, Huang Y, Wang J. MINERVA: A facile strategy for SARS-CoV-2 whole genome deep sequencing of clinical samples. Mol Cell. 2020, 80:1123-1134. (IF: 15.584)
6) Du P, Song C, Li R, Song Y, Li J, Ding N, Zhang J, Song R, Han J, Gao G, Yue J, Duan A, Huang Y, An J, Wang J, Zhang F, Chen C, Zeng H*. Specific re-distribution of SARS-CoV-2 variants in the respiratory system and intestinal tract. Clin Infect Dis. 2020 Oct 22:ciaa1617. doi: 10.1093/cid/ciaa1617. (IF: 8.313)
7) Du P, Ding N, Li J, Zhang F, Wang Q, Chen Z, Song C, Han K, Xie W, Liu J, Wang L, Wei L, Ma S, Hua M, Yu F, Wang L, Wang W, An K, Chen J, Liu H, Gao G, Wang S, Huang Y, Wu AR, Wang J, Liu D, Zeng H*, Chen C. Genomic surveillance of COVID-19 cases in Beijing. Nat Commun. 2020, 11:5503. (IF: 12.121)
8) Kong Y, Wang Y, Wu X, Han J, Li G, Hua M, Han K, Zhang H, Li A, Zeng H*. Storm of soluble immune checkpoints associated with disease severity of COVID-19. Signal Transduct Target Ther. 2020, 5:192. (IF: 13.493)
9) Chen C, Gao G, Xu Y, Pu L, Wang Q, Wang L, Wang W, Song Y, Chen M, Wang L, Yu F, Yang S, Tang Y, Zhao L, Wang H, Wang Y, Zeng H*, Zhang F. SARS-CoV-2-positive sputum and feces after conversion of pharyngeal samples in patients with COVID-19. Ann Intern Med. 2020, 172:832-834. (IF: 21.317)
10) Zhang N, Zhu L, Zhang Y, Zhou C, Song R, Yang X, Huang L, Xiong S, Huang X, Xu F, Wang Y, Wan G, Chen Z, Li A, Zhan Q, Zeng H. Circulating rather than alveolar extracellular DNA levels predict outcomes in influenza: a cohort study. J Infect Dis. 2020 222:1145-1154. (IF: 5.022)
11) Zhao C, Jia B, Wang M, Schell TD, Claxton DF, Ehmann WC, Rybka WB, Mineishi S, Naik S, Songdej N, Sivik JM, Hohl RJ, Zeng H*, Zheng H. Multi-dimensional analysis identifies an immune signature predicting response to decitabine treatment in elderly patients with AML. Br J Haematol. 2020,188:674-684. (IF: 5.518)
12) Kong Y, Jia B, Zhao C, Claxton DF, Sharma A, Annageldiyev C, Fotos JS, Zeng H, Paulson RF, Prabhu KS, Zheng H. Downregulation of CD73 associates with T cell exhaustion in AML patients. J Hematol Oncol. 2019, 12:40.
13) Li J, Du P, Ye AY, Zhang Y, Song C, Zeng H*, Chen C*. GPA: A Microbial Genetic Polymorphisms Assignments Tool in Metagenomic Analysis by Bayesian Estimation. Genom Proteom Bioinf. 2019, 17:106-117.
14) Chen C, Jiang D, Ni M, Li J, Chen Z, Liu J, Ye H, Wong G, Li W, Zhang Y, Wang B, Bi Y, Chen D, Zhang P, Zhao X, Kong Y, Shi W, Du P, Xiao G, Ma J, Gao GF, Cui J, Zhang F, Liu W, Bo X, Li A, Zeng H*, Liu D. Phylogenomic analysis unravels evolution of yellow fever virus within hosts. PLoS Negl Trop Dis. 2018,12:e0006738. (IF: 3.885)
15) Song Y, Wang B, Song R, Hao Y, Wang D, Li Y, Jiang Y, Xu L, Ma Y, Zheng H, Kong Y*, Zeng H*. T-cell Immunoglobulin and ITIM Domain Contributes to CD8+ T-cell Immunosenscence. Aging Cell. 2018 17:e12716. (IF: 7.238)
16) Zhu L, Liu L, Zhang Y, Pu L, Liu J, Li X, Chen Z, Hao Y, Wang B, Han J, Li G, Liang S, Xiong H, Zheng H, Li A, Xu J*, Zeng H*. High level of neutrophil extracellular traps correlates with poor prognosis of severe influenza A infection. J Infect Dis. 2018, 217:428-437. (IF: 5.022)
17) Zhu L, Kong Y, Zhang J, Claxton DF, Ehmann WC, Rybka WB, Palmisiano ND, Wang M, Jia B, Bayerl M, Schell TD, Hohl RJ, Zeng H*, Zheng H. Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia. J Hematol Oncol. 2017, 10:124.
18) Xing Z, Han J, Hao X, Wang J, Jiang C, Hao Y, Wang H, Shen L, Dong X, Li T, Li G, Zhang J, Hou X*, Zeng H*. Immature monocytes contribute to cardiopulmonary bypass-induced acute lung injury by generating inflammatory descendants. Thorax, 2017, 72: 245-255.
19) Kong Y, Li Y, Zhang W, Yuan S, Winkler R, Kr?hnert U, Han J, Lin T, Zhou Y, Miao P, Wang B, Zhang J, Yu Z, Zhang Y, Kosan C, Zeng H*. Sepsis-induced thymic atrophy is associated with defects in early lymphopoiesis. Stem Cells. 2016, 34:2902-2915.
20) Kong Y, Zhu L, Schell TD, Zhang J, Claxton DF, Ehmann WC, Rybka W, George MR, Zeng H*, Zheng H. TIGIT associates with CD8+ T cell exhaustion and poor clinical outcome in AML patients. Clin Cancer Res. 2016 22:3057-66.
21) He G, Zhang H, Zhou J, Wang B, Chen Y, Kong Y, Xie X, Wang X, Fei R, Wei L1, Chen H, Zeng H*. Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma. J Exp Clin Cancer Res. 2015, 18:141.
22) Kong Y, Zhang J, Claxton DF, Ehmann WC, Rybka WB, Zhu L, Zeng H, Schell TD, Zheng H. PD-1hiTIM-3+ T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation. Blood Cancer J. 2015, 5:e330.
23) Hou X*, Yang X, Du Z, Xing J, Li H, Jiang C, Wang J, Xing Z, Li S, Li X, Yang F, Wang H and Zeng H*. Superior vena cava drainage improves upper body oxygenation during veno-arterial extracorporeal membrane oxygenation in sheep. Crit Care 2015, 19:68.
24) Zhu L#, Meng Q#, Liang S, Ma Y, Li R, Li G, Zeng H*. The transcript.on factor GFI1 negatively regulates NLRP3 inflammasome activation in macrophages. FEBS Lett. 2014, 588:4513-4519.
25) Shi G#, Han J#, Liu G, Hao Y, Ma Y, Li T, Wu X, Zhang H, Liu Y, Wang B, Kong Y, Zhou J*, Zeng H*. Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative pathway in CSF of bacterial meningitis patients. Eur J Immunol. 2014, 44:420-430.
26) Zhou H#, Zhao H#, Hao Y#, Song C, Han J, Zhang J, Gao G, Han N, Yang D, Li Y, Zhang F, Zeng H *. Excessive conversion and impaired thymic output contribute to disturbed regulatory T-cell homeostasis in AIDS patients with low CD4 counts. AIDS. 2013, 27:1059-1069.
27) Hou J, Sun Y*, Hao Y, Zhuo J, Liu X, Bai P, Han J, Zheng X, Zeng H *. Imbalance between subpopulations of regulatory T cells in COPD. Thorax. 2013, 68: 1131-1139.
28) Khandanpour C, Kosan C, Gaudreau MC, Dührsen U, Hébert J, Zeng H* and M?r?y T*. Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Stem Cells. 2011, 29: 376-385.
29) Sharif-Askari E, Vassen L, Kosan C, Khandanpour C, Gaudreau MC, Heyd F, Okayama T, Jin J, Rojas ME, Grimes HL, Zeng H*, M?r?yT*. Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65. Mol Cell Biol. 2010, 30:3929-3942.
30) Zeng H, Yucel R, Kosan C, Klein-Hitpass L, M?r?y T. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 2004, 23:4116.
31) Karsunky H, Zeng H, Schmidt T, Zevnic B, Kluge R, Schimid KW, Duhrsen U, M?r?y T. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet. 2002, 30:295-300.
32) Zeng H, Masuko M, Jin L, Neff T, Otto KG, Blau CA. Receptor specificity in the self-renewal and differentiation of primary multipotential hemopoietic cells. Blood 2001, 98:328-334.
